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Charles Byrne (human curiosity) : ウィキペディア英語版
Charles Byrne (giant)

Charles Byrne (1761–1783) or "The Irish Giant", was a man regarded as a curiosity or freak in London in the 1780s. Byrne's exact height is of some conjecture. Some accounts refer to him as from tall; however, skeletal evidence places him at just over .
Byrne's family lived in a remote part of northeast Tyrone called Drummullan, not far from the shores of Lough Neagh. It is said that Byrne had been conceived on top of a haystack, and that this was the cause of his great height. Little is known of Byrne's family other than that his parents were ordinary people, and that they were not unusually tall.
At the age of 21 he left his home in Littlebridge, Ireland, and travelled to London to seek his fortune. He found work at Cox's Museum, an establishment not unlike P. T. Barnum's American Museum. He moved in next door in an elegant apartment with custom-built furniture at the cane-shop, in Spring Garden-gate.
He soon became the toast of the town; a 6 May 1782 newspaper report bears out: "However striking a curiosity may be, there is generally some difficulty in engaging the attention of the public; but even this was not the case with the modern living Colossus, or wonderful Irish Giant."
Fame and wealth soon overtook Byrne, and he took to drinking excessively. According to newspaper reports he was out drinking when his pocket was picked of his 700-pound life savings. Inconsolable, he tried to drown his sorrows in drink and died in June 1783, in his apartment on Cockspurstreet, Charing Cross, at the age of twenty-two.
It was rumoured that Byrne was so afraid that doctors would dissect his corpse that on his deathbed he requested to be buried at sea.
Reports at the time indicated that Byrne had paid fishermen near Bristol to bury him at sea. After being bribed by John Hunter, however, they allowed the body to be pulled behind their boat until nightfall when they pulled the corpse back in and sold it to the surgeon for £130 (''2013: £''). His 2.31-m (7 ft 7 in) skeleton now resides in the Hunterian Museum at the Royal College of Surgeons in London.〔

==Medical condition==
The American surgeon Harvey Cushing studied Byrne's bones in 1909 and found that Byrne had had a pituitary tumour based on an enlarged pituitary fossa. In 2011, British and German researchers determined the cause of Byrne's gigantism. They extracted DNA from Byrne's teeth and found that he had a rare mutation in his ''AIP'' gene that is involved in pituitary tumours. The researchers also found that four contemporary families living in Northern Ireland which have a history of related pituitary disorders also carried this mutation. The researchers inferred that Byrne and these families had a common ancestor about 57 to 66 generations ago (1425 to 1650 years ago).

抄文引用元・出典: フリー百科事典『 ウィキペディア(Wikipedia)
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